Premenstrual Spotting Found to be Predictive of Endometriosis among Women with Infertility

In observance of Endometriosis Awareness Month, this week’s Featured Research focuses on a study linking specific observations a woman can make at home to signs of endometriosis. Read through for more details, and stay tuned for more posts about endometriosis this month.

 March 16th, 2017

by Richard Fehring, PhD, RN

Fertility chart education

Background

Endometriosis can be a debilitating disease affecting about 6-10% of reproductive age women and is associated with pelvic pain and infertility. Since endometriosis is a progressive disease, diagnosing and surgically treating it early is important, i.e., before it becomes deeply invasive and infiltrating. Although there is some association of endometriosis with pelvic pain, the most definitive diagnostic procedure is through visual laparoscopy. Although laparoscopy is a fairly safe procedure, there are surgical risks and discomfort. Non-surgical diagnostic indicators would be beneficial for early and non-invasive detection. One potential indicator of early endometriosis is pre-menstrual spotting, i.e., light menstrual bleeding before a frank menses. Therefore, researchers sought to determine if premenstrual spotting (of 2 days or more) was predictive of endometriosis among sub-fertile women (Heitmann, Langan, Huang, Chow, Burney 2014).

Methodology

The participants for this study were selected from the records of all women who underwent laparoscopy for an infertility assessment – most of whom had pelvic pain – from March 2009 to March 2011 at a tertiary medical center. All participants completed a three page infertility assessment that included questions as to pelvic pain during menses and intercourse, and whether they had spotting before the normal menstrual flow. The researchers only included the symptom if the premenstrual bleeding was two days or more before the onset of menses. They were able to obtain records of 80 women who met their criteria, and of these, 32 reported premenstrual spotting of two days or more.

Results

Of the women who reported premenstrual spotting, 89%, or 34 of 38, were diagnosed with endometriosis as compared to only 11 of 42 (26%) in the group of women who did not experience premenstrual spotting (p < .001). They also found that, of the three menstrual symptoms of dysmenorrhea, dyspareunia, or premenstrual spotting, premenstrual spotting was the most predictive, i.e., 81% compared to 76% for dysmenorrhea, and 58% for dyspareunia. A stated limitation of the study was the retrospective design. However, they concluded that if this association of premenstrual spotting and endometriosis is validated in prospective studies that it could be used for the identification of women who would benefit most from laparoscopic evaluation and treatment.

Comments

I would also add that a prospective study that includes prospective charting of the menstrual cycle that includes natural biological markers of fertility and levels of menstrual bleeding, i.e., charting systems that are commonly found in natural family planning systems, would provide a more accurate assessment of premenstrual spotting. This study also reinforces the benefit of charting the menstrual cycle as a vital sign for women’s health.

Source

Heitmann, R.J., K.I. Langan, R. R. Huang, G. E. Chow, R. O. Burney. 2014. Premenstrual spotting of > 2 days is strongly associated with histologically confirmed endometriosis in women with infertility.  American Journal of Obstetrics and Gynecology, 2014:211:358.e1-6.

Republished from Current Medical Research with permission from the USCCB.